Abstract
Objectives
The objective of this literature review was to evaluate multimodal therapies and interventions
that help prevent progression and manage pain in children with OI.
Design
A systematic review of literature utilizing PRISMA guidelines.
Data sources
The Cumulative Index to Nursing and Allied Health Literature (CINAHL) Complete, PubMed,
PsycINFO, UpToDate, and ProQuest Nursing & Allied Health Source.
Review/Analysis methods
Existing literature on pain management in pediatric patients diagnosed with OI was
reviewed and appraised. Fifteen studies met the criteria for review.
Results
Results indicated that therapies addressing pain management are most effective when
they use a multimodal approach that promotes bone strength, psychological support,
reduces the risk of fractures, increases bone stability, and maintains physiological
function. Four multimodal treatments for pain management in children with OI were
identified including bisphosphonate therapy, surgical intervention, physical therapy,
and psychosocial support.
Conclusions
Developing a finite understanding of the utilization of multimodal therapies to manage
and treat pain can assist in engineering treatments that improve the quality of life
for children diagnosed with OI.
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References
Beary, J., & Chines, A. (2019). Osteogenesis imperfecta: Management and prognosis. UpToDate. Retrieved Jan 25, 2019, from https://www-uptodate-com.ezproxy.depaul.edu/contents/osteogenesis-imperfecta-management-and-prognosis?search=osteogenesis%20imperfecta%20children&source=search_result&selectedTitle=2~77&usage_type=default&display_rank=2
- Results of rodding and impact on ambulation and refracture in osteogenesis imperfecta: Study of 21 children.Indian J Orthop. 2019; 53: 554-559
- The impact of psycho-educational training on the psychosocial adjustment of caregivers of osteogenesis imperfecta patients.J Clin Res Pediatr Endocrinol. 2014; 6: 84-92
- The impact of severe osteogenesis imperfecta on the lives of young patients and their parents - a qualitative analysis.BMC pediatrics. 2013; 13: 153
- Re-alignment and intramedullary rodding of the humerus and forearm in children with osteogenesis imperfecta: revision rate and effect on fracture rate.J Child Orthop. 2017; 11: 185-190
- Cyclic bisphosphonate therapy reduces pain and improves physical functioning in children with osteogenesis imperfecta.BMC Musculoskelet Disord. 2018; 19: 1-7
- A specialized rehabilitation approach improves mobility in children with osteogenesis imperfecta.J Musculoskelet Neuronal Interact. 2014; 14: 445-453
- Development of scoliosis in young children with osteogenesis imperfecta undergoing intravenous bisphosphonate therapy.J Bone Miner Metab. 2019; 37: 545-553
- Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement.J Bone Miner Res. 2005; 20: 977-986
- Therapy with pamidronate in children with osteogenesis imperfecta.Drug Des Devel Ther. 2017; 11: 2507-2515
- Managing the patient with osteogenesis imperfecta: A multidisciplinary approach.J Multidiscip Healthc. 2017; 10: 145-155
- Consensus statement on physical rehabilitation in children and adolescents with osteogenesis imperfecta.Orphan J Rare Dis. 2018; 13: 12-24
- Pain experiences of children and adolescents with osteogenesis imperfecta: An integrative literature review.Clin J Pain. 2017; 33: 271-280
- PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews.BMJ. 2021; 372: 1-9
- Intravenous bisphosphonate therapy of young children with osteogenesis imperfecta: Skeletal findings during follow up throughout the growing years.J Bone Miner Res. 2015; 30: 2150-2157
- Ostogensis imperfecta- clinical and molecular diversity.Eur Cell Mater. 2003; 5: 17-41
- Family experience with osteogenesis imperfecta type 1: The most distressing situations.Disabil Rehabil. 2018; 40: 2281-2287
- Musculoskeletal functional outcomes in children with osteogenesis imperfecta: Associations with disease severity and pamidronate therapy.J Pediatr Orthop. 2014; 34: 118-122
- [Osteogenesis imperfecta operative treatment on lower extremities in children with osteogenesis imperfecta.].Chir Narzadow Ruchu Ortop Pol. 2005; 70: 189-193
- Osteogenesis imperfecta in children and adolescents-new developments in diagnosis and treatment.Osteoporos Int. 2016; 27: 3427-3437
- Chronic pain as a symptom or a disease: The IASP classification of chronic pain for the International Classification of Diseases (ICD-11).Pain. 2019; 160: 19-27
- Pain and quality of life of children and adolescents with osteogenesis imperfecta over a bisphosphonate treatment cycle.Eur J Pediatr. 2018; 177: 891-902
- Physical training in children with osteogenesis imperfecta.J Pediatr. 2008; 152: 111-116
- Health-related quality of life of children and adolescents with osteogenesis imperfecta: A cross-sectional study using PedsQL™.BMC Pediatr. 2018; 18: 95
- Bisphosphonate therapy and osteogenesis imperfecta: The lived experience of children and their mothers.J Spec Pediatr Nurs. 2017; 22: 1-7
- WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses.World Health Organization, 2012 (Retrieved August 16, 2022, from )
Article info
Publication history
Published online: October 04, 2022
Accepted:
August 28,
2022
Received in revised form:
August 24,
2022
Received:
January 17,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
