Pain Management Nursing
Volume 13, Issue 1 , Pages 60-65 , March 2012

The Sensitization Model to Explain How Chronic Pain Exists Without Tissue Damage

  • C. Paul van Wilgen, PhD

      Affiliations

    • Corresponding Author InformationAddress correspondence to C. Paul van Wilgen, University Center for Sport, Exercise and Health, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
  • ,
  • Doeke Keizer, PhD

Received 23 July 2009 ,Revised 1 March 2010 ,Accepted 1 March 2010.

References 

  1. Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. European Journal of Pain. 2005;9:463–484
  2. Banic B, Petersen-Felix S, Andersen OK, Radanov BP, Villiger PM, Arendt-Nielsen L, et al. Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain. 2004;107:7–15
  3. Baron R. Mechanisms of disease: Neuropathic pain—A clinical perspective. Nature Clinical Practice Neurology. 2006;2:95–106
  4. Blomberg AM, Hylander I, Tornkvist L. District nurses' involvement in pain care: A theoretical model. Journal of Clinical Nursing. 2008;17:2022–2031
  5. Davis KD. Studies of pain using functional magnetic resonance imaging. In:  Casey KL,  Bushnell MC editor. Pain imaging, progress in pain research and management. Seattle: IASP Press; 2000;p. 195–210
  6. De Wit R, van Dam F, Zandbelt L, van Buuren A, van der Heijden K, Leenhouts G, et al. A pain education program for chronic cancer pain patients: Follow up results from a randomized controlled trial. Pain. 1997;73:55–69
  7. Engel GL. The clinical application of the biopsychosocial model. American Journal Psychiatry. 1980;137:535–544
  8. Fitzpatrick R. Telling patients there is nothing wrong. British Medical Journal. 1996;10:311–312
  9. Gracely RH, Geisser ME, Giesecke T, Grant MAB, Petzke F, Williams DA, et al. Pain catastrophizing and neural responses to pain among patients with fibromyalgia. Brain. 2004;127:835–843
  10. Gray JA, McNaughton N. The neurophysiology of anxiety. Oxford: Oxford University Press; 2000;
  11. Guzman J, Esmail R, Karjalainen K, Malmivaara A, Irvin E, Bombardier C. Multidisciplinary rehabilitation for chronic low back pain: Systematic review. British Medical Journal. 2001;322:1511–1516
  12. Hahn SR, Thompson KS, Wills TA, Stern V, Budner NS. The difficult doctor–patient relationship: Somatization, personality and psychopathology. Journal of Clinical Epidemiology. 1994;47:647–657
  13. Hsieh JC, Belfrage M, Stone-Elander S, Hansson P, Ingvar M. Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain. 1995;63:225–236
  14. Kasch H, Qerama E, Bach FW, Jensen TS. Reduced cold pressor pain tolerance in nonrecovered whiplash patients: A 1-year prospective study. European Journal of Pain. 2005;9:561–569
  15. Kilo S, Schmelz M, Koltzenburg M, Handwerker HO. Different patterns of hyperalgesia induced by experimental inflammation in human skin. Brain. 1994;117:385–396
  16. Koltzenburg M, Torebjork HE, Wahren LK. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain. 1994;117:579–591
  17. Kurata J. Functional magnetic resonance imaging explained for pain research and medicine. Regional Anesthesia and Pain Medicine. 2002;27:68–71
  18. Lame IE, Peters ML, Vlaeyen JWS, van Kleef M, Patijn J. Quality of life in chronic pain is more associated with beliefs about pain, than with pain intensity. European Journal of Pain. 2005;9:15–24
  19. LaMotte RH, Shain CN, Simone DA, Tsai EF. Neurogenic hyperalgesia: Psychophysical studies of underlying mechanisms. Journal of Neurophysiology. 1991;66:190–211
  20. Merskey H, Bogduk N. Classification of chronic pain. Description of chronic pain syndromes and definitions of pain terms. 2nd Ed.. Seattle: IASP Press; 1994;
  21. Millan MJ. Descending control of pain. Progress in Neurobiology. 2002;66:355–474
  22. Moisset X, Bouhassira D. Brain imaging of neuropathic pain. Neuroimage. 2007;7:S80–S88
  23. Moseley GL, Nicholas MK, Hodges PW. A randomized controlled trail of intensive neurophysiology and education in chronic low back pain. Clinical Journal of Pain. 2004;20:324–330
  24. Petrovic P, Kalso E, Petersson KM, Ingvar M. Placebo and opioid analgesia—Imaging a shared neuronal network. Science. 2002;295:1737–1740
  25. Peyron R, Laurent B, Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis. Clinical Neurophysiology. 2000;30:263–288
  26. Ploghaus A, Narain C, Beckmann CF, Clare S, Bantick S, Wise R, et al. Exacerbation of pain by anxiety is associated with activity in a hippocampal network. Journal of Neuroscience. 2000;15:9896–9903
  27. Ring A, Dowrick CF, Humphris GM, Davies J, Salmon P. The somatising effect of clinical consultation: What patients and doctors say and do not say when patients present medically unexplained physical symptoms. Social Science Medicine. 2005;61:1505–1515
  28. Torebjork HE, Lundberg LE, LaMotte RH. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans. Journal of Physiology. 1992;448:765–780
  29. Turk DC, Okifuji A. Psychological factors in chronic pain: Evolution and revolution. Journal of Consulting and Clinical Psychology. 2002;70:678–690
  30. Van der Peet EH, van der Beuken-van Everdingen MHJ, Patijn J, Schouten HC, van Kleef M, Courtens AM. Randomized clinical trial of an intensive nursing-based pain education program for cancer outpatients suffering form pain. Support Cancer Care. 2008;23:
  31. Van Tulder MW, Koes BW, Bouter LM. A cost-of-illness study of back pain in the Netherlands. Pain. 1995;62:233–240
  32. Verhaak PFM, Kerssens JJ, Dekker J, Sorbi MJ, Bensing JM. Prevalence of chronic benign pain disorders among adults: A review of the literature. Pain. 1998;77:231–239
  33. Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, et al. Placebo-induced changes in fMRI in the anticipation and experience of pain. Science. 2004;303:1162–1167
  34. Wang H, Sun H, Della Penna K, Benz RJ, Xu J, Gerhold DL, et al. Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases. Neuroscience. 2002;114:529–546
  35. Walsh DA, Radcliffe JC. Pain beliefs and perceived physical disability of patients with chronic low back pain. Pain. 2002;97:23–31
  36. Woolf CJ, Salter MW. Neuronal plasticity: Increasing the gain in pain. Science. 2000;288:1765–1769
  37. Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, et al. COMT val∗‖8met genotype affects μ-opioid neurotransmitter responses to a pain stressor. Science. 2003;299:1240–1243

PII: S1524-9042(10)00032-9

doi: 10.1016/j.pmn.2010.03.001

Pain Management Nursing
Volume 13, Issue 1 , Pages 60-65 , March 2012